PCDHA4 anticorps (C-Term)

N° du produit ABIN2782799

Détail du produit anti-PCDHA4 anticorps

Antigène: PCDHA4 (Protocadherin alpha 4 (PCDHA4))

Épitope: C-Term

Reactivité: Humain, Cobaye, Rat, Boeuf (Vache), Chien, Cheval, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCDHA4 est non-conjugé

Application: Western Blotting (WB)

Séquence: SGYNAWLSYE LQPETASASI PFRVGLYTGE ISTTRALDET DAPRQRLLVL

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PCDHA4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PCDHA4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 947 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PCDHA4

Antigène: PCDHA4 (Protocadherin alpha 4 (PCDHA4))

Autre désignation: PCDHA4 (PCDHA4 Produits)

Synonymes: anticorps CNR1, anticorps CNRN1, anticorps CRNR1, anticorps PCDH-ALPHA4, anticorps Cnr1, anticorps Crnr1, anticorps R75250, anticorps PCDHA4, anticorps CNRv4, anticorps Pcdha4, anticorps protocadherin alpha 4, anticorps protocadherin alpha-4, anticorps PCDHA4, anticorps Pcdha4, anticorps LOC100713594, anticorps LOC100629843

Sujet: The gene encoding PCDHA4 is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. PCDHA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
Alias Symbols: CNR1, CNRN1, CRNR1, MGC138307, MGC142169, PCDH-ALPHA4
Protein Interaction Partner: SGTA, LRIF1, CCDC90B, RBM48, IGSF21, SETDB1, C14orf1, UNC119, GDF9, RELN, TLE1, TP53, GAPDH, EEF1A1, APLP1,
Protein Size: 947

Poids moléculaire: 99 kDa

ID gène: 56144

NCBI Accession: NM_018907, NP_061730

UniProt: Q9UN74