PLEKHO1 anticorps (N-Term)

N° du produit ABIN2783148

Détail du produit anti-PLEKHO1 anticorps

Antigène: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Épitope: N-Term

Reactivité: Humain, Rat, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLEKHO1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG

Homologie: Cow: 86%, Human: 100%, Pig: 86%, Rat: 82%

Attributs du produit: This is a rabbit polyclonal antibody against PLEKHO1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PLEKHO1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 409 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PLEKHO1

Antigène: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Autre désignation: PLEKHO1 (PLEKHO1 Produits)

Synonymes: anticorps CKIP-1, anticorps OC120, anticorps 2810052M02Rik, anticorps Ckip1, anticorps JZA-20, anticorps Jza2, anticorps RGD1311487, anticorps ckip-1, anticorps plekho1, anticorps si:dkey-200h23.2, anticorps pleckstrin homology domain containing O1, anticorps pleckstrin homology domain containing, family O member 1, anticorps pleckstrin homology domain containing, family O member 1a, anticorps PLEKHO1, anticorps Plekho1, anticorps plekho1a

Sujet: PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Alias Symbols: CKIP-1, OC120, RP11-458I7.3
Protein Interaction Partner: PLEKHO1, AKT3, AKT2, AKT1, UBC, GSK3B, TRAF6, Arpc1a, Stub1, Rps3a1, SMURF1, PSMC5, USP7, C10orf88, RPS20, IFI35, DNAJB1, FLNB, CSNK2A1, SMAD5, JUND, JUN, CASP3,
Protein Size: 409

Poids moléculaire: 46 kDa

ID gène: 51177

NCBI Accession: NM_016274, NP_057358

UniProt: Q53GL0