PDHA1 anticorps (C-Term)

N° du produit ABIN2783236

Détail du produit anti-PDHA1 anticorps

Antigène: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Porc, Poisson zèbre (Danio rerio), Cobaye, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDHA1 est non-conjugé

Application: Western Blotting (WB)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 82%

Attributs du produit: This is a rabbit polyclonal antibody against PDHA1. It was validated on Western Blot using a cell lysate as a positive control.

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PDHA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 390 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PDHA1

Antigène: PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))

Autre désignation: PDHA1 (PDHA1 Produits)

Synonymes: anticorps PDHA, anticorps PDHCE1A, anticorps PHE1A, anticorps Pdha-1, anticorps pdha, anticorps phe1a, anticorps pdhce1a, anticorps im:6895726, anticorps pdha1, anticorps wu:fd18b01, anticorps wu:fo96f03, anticorps zgc:73271, anticorps zgc:86692, anticorps Pdha1, anticorps wu:fp73b04, anticorps zgc:92705, anticorps NI36_05250, anticorps pdha1-a, anticorps pdha1-b, anticorps pyruvate dehydrogenase E1 alpha 1 subunit, anticorps pyruvate dehydrogenase E1 alpha 1, anticorps pyruvate dehydrogenase (lipoamide) alpha 1, anticorps pyruvate dehydrogenase (lipoamide) alpha 1 pseudogene, anticorps 2-oxo acid dehydrogenase, anticorps pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha, anticorps pyruvate dehydrogenase alpha subunit protein, anticorps pyruvate dehydrogenase (acetyl-transferring) protein, alpha subunit, anticorps precursor of dehydrogenase pyruvate dehydrogenase E1 component alpha subunit, anticorps pyruvate dehydrogenase, anticorps pyruvate dehydrogenase E1 alpha 1 subunit a, anticorps pyruvate dehydrogenase E1 alpha 1 subunit b, anticorps pyruvate dehydrogenase E1 component subunit alpha, anticorps pyruvate dehydrogenase (lipoamide) alpha 1 S homeolog, anticorps PDHA1, anticorps Pdha1, anticorps pdha1, anticorps LOC719277, anticorps VNG_RS07485, anticorps RR_RS04695, anticorps pdhA1, anticorps pdha1a, anticorps pdha1b, anticorps NI36_RS05240, anticorps pdha1.S

Sujet: The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1), dihydrolipoyl transacetylase (DLAT), and dihydrolipoyl dehydrogenase (DLD). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex.The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1), dihydrolipoyl transacetylase (DLAT, MIM 608770) (E2, EC 2.3.1.12), and dihydrolipoyl dehydrogenase (DLD, MIM 238331) (E3, EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits. The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PDHA, PDHCE1A, PHE1A
Protein Interaction Partner: HUWE1, SUMO2, UBC, GINS4, DCPS, NCDN, VCL, PPP1R2, MSN, ASL, ADRB2, ITGA4, HNRNPDL, PDHX, SDHA, PDHB, OGDH, GTF2I, DLAT, CUL3, SIRT7, ATG101, WDR20, BABAM1, USP19, PDP1, EIF6, PDK4, PDK3, PDK2, PDK1, PDHA1, DGKE,
Protein Size: 390

Poids moléculaire: 40 kDa

ID gène: 5160

NCBI Accession: NM_000284, NP_000275

UniProt: P08559

Pathways: L'effet Warburg