ALG2 anticorps (C-Term)

N° du produit ABIN2783587

Détail du produit anti-ALG2 anticorps

Antigène: ALG2 (Asparagine-Linked Glycosylation 2, alpha-1,3-Mannosyltransferase Homolog (ALG2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Chévre, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALG2 est non-conjugé

Application: Western Blotting (WB)

Séquence: QSDLGQYVTF LRSFSDKQKI SLLHSCTCVL YTPSNEHFGI VPLEAMYMQC

Homologie: Cow: 100%, Dog: 93%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ALG2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human ALG2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 416 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ALG2 (ABIN2783587)

Cossins, Belaya, Hicks, Salih, Finlayson, Carboni, Liu, Maxwell, Zoltowska, Farsani, Laval, Seidhamed, Donnelly, Bentley, McGowan, Müller, Palace, Lochmüller, Beeson: "Congenital myasthenic syndromes due to mutations in ALG2 and ALG14." dans: Brain : a journal of neurology, Vol. 136, Issue Pt 3, pp. 944-56, (2013) (PubMed).

Rind, Schmeiser, Thiel, Absmanner, Lübbehusen, Hocks, Apeshiotis, Wilichowski, Lehle, Körner: "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip." dans: Human molecular genetics, Vol. 19, Issue 8, pp. 1413-24, (2010) (PubMed).

Détails sur ALG2

Antigène: ALG2 (Asparagine-Linked Glycosylation 2, alpha-1,3-Mannosyltransferase Homolog (ALG2))

Autre désignation: ALG2 (ALG2 Produits)

Synonymes: anticorps CDGIi, anticorps NET38, anticorps hALPG2, anticorps 1110018A23Rik, anticorps 1300013N08Rik, anticorps ALPG2, anticorps MNCb-5081, anticorps im:7145131, anticorps ALG2, alpha-1,3/1,6-mannosyltransferase, anticorps asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase), anticorps ALG2, alpha-1,3/1,6-mannosyltransferase L homeolog, anticorps GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase, anticorps ALG2, anticorps Alg2, anticorps alg2.L, anticorps alg2

Sujet: ALG2 is a member of the glycosyltransferase 1 family. It acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDGIi, FLJ14511, hALPG2, NET38
Protein Interaction Partner: UBC, PLSCR3, SHISA5, PDCD6IP, ALG2, VPS28, PTPN23, SEC31A, TSG101, LAMP1, HSP90AA1, PTK2B, ANXA11, ANXA7, VPS37A, PEF1, SRI,
Protein Size: 416

Poids moléculaire: 47 kDa

ID gène: 85365

NCBI Accession: NM_033087, NP_149078

UniProt: Q9H553