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Protocadherin gamma Subfamily A, 4 (PCDHGA4) (N-Term) anticorps

PCDHGA4 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2783724
  • Antigène Voir toutes Protocadherin gamma Subfamily A, 4 (PCDHGA4) Anticorps
    Protocadherin gamma Subfamily A, 4 (PCDHGA4)
    Épitope
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)
    Hôte
    • 3
    • 1
    Lapin
    Clonalité
    • 4
    Polyclonal
    Conjugué
    • 4
    Inconjugué
    Application
    • 4
    • 1
    Western Blotting (WB)
    Séquence
    GDPVRSGTAR ILIILVDTND NAPVFTQPEY HVSVRENVPV GTRLLTVKAT
    Homologie
    Cow: 86%, Dog: 93%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against PCDHGA4. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human PCDHGA4
    Top Product
    Discover our top product PCDHGA4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 820 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    Protocadherin gamma Subfamily A, 4 (PCDHGA4)
    Autre désignation
    PCDHGA4 (PCDHGA4 Produits)
    Synonymes
    anticorps PCDH-GAMMA-A4, anticorps Pcdhga3, anticorps protocadherin gamma subfamily A, 4, anticorps PCDHGA4, anticorps Pcdhga4
    Sujet
    PCDHGA4 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGA4 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
    Alias Symbols: PCDH-GAMMA-A4
    Protein Size: 820
    Poids moléculaire
    86 kDa
    ID gène
    56111
    NCBI Accession
    NM_032053, NP_114442
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