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SIGIRR anticorps (C-Term)

SIGIRR Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Porc WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2783841
  • Antigène Voir toutes SIGIRR Anticorps
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Épitope
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    C-Term
    Reactivité
    Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Porc
    Hôte
    • 24
    • 4
    • 1
    Lapin
    Clonalité
    • 24
    • 5
    Polyclonal
    Conjugué
    • 21
    • 6
    • 2
    Cet anticorp SIGIRR est non-conjugé
    Application
    • 27
    • 13
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD FYCLVSKDDM
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against SIGIRR. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR
    Top Product
    Discover our top product SIGIRR Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 224 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
    Autre désignation
    SIGIRR (SIGIRR Produits)
    Synonymes
    anticorps TIR8, anticorps AI256711, anticorps sc:d148, anticorps RGD1306732, anticorps single Ig and TIR domain containing, anticorps single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, anticorps SIGIRR, anticorps Sigirr, anticorps sigirr
    Sujet
    SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
    Alias Symbols: MGC110992, TIR8
    Protein Interaction Partner: APP, UBC, SIGIRR, TLR9, TLR5, TLR4, TRAF6, IRAK1, RPN1, IL1R1, ENO2,
    Protein Size: 224
    Poids moléculaire
    25 kDa
    ID gène
    59307
    UniProt
    Q6IA17
    Pathways
    Toll-Like Receptors Cascades
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