ULBP1 anticorps (N-Term)

N° du produit ABIN2783974

Détail du produit anti-ULBP1 anticorps

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULBP1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ULBP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ULBP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 244 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ULBP1

Antigène: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Autre désignation: ULBP1 (ULBP1 Produits)

Synonymes: anticorps RAET1I, anticorps A430108B07Rik, anticorps MULT1, anticorps ULBP1, anticorps UL16 binding protein 1, anticorps UL16 binding protein 21, anticorps NKG2D ligand 1, anticorps ULBP1, anticorps ULBP21, anticorps Ulbp1, anticorps LOC100683099

Sujet: ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Alias Symbols: RAET1I
Protein Interaction Partner: MARCH9, MARCH4, UBC, RAET1G, KLRC4,
Protein Size: 244

Poids moléculaire: 28 kDa

ID gène: 80329

NCBI Accession: NM_025218, NP_079494

UniProt: Q9BZM6

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process