SIGLEC10 anticorps (Middle Region)

N° du produit ABIN2784077

Détail du produit anti-SIGLEC10 anticorps

Antigène: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Épitope: Middle Region

Reactivité: Humain, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC10 est non-conjugé

Application: Western Blotting (WB)

Séquence: CHVDFSRKGV SAQRTVRLRV AYAPRDLVIS ISRDNTPALE PQPQGNVPYL

Homologie: Dog: 79%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SIGLEC10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC10

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 697 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SIGLEC10 (ABIN2784077)

Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns." dans: Genome biology, Vol. 8, Issue 8, pp. R154, (2008) (PubMed).

Détails sur SIGLEC10

Antigène: SIGLEC10 (Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10))

Autre désignation: SIGLEC10 (SIGLEC10 Produits)

Synonymes: anticorps PRO940, anticorps SIGLEC-10, anticorps SLG2, anticorps Siglecg, anticorps SIGLEC10, anticorps slg2, anticorps pro940, anticorps siglec-10, anticorps sialic acid binding Ig like lectin 10, anticorps sialic acid binding Ig-like lectin 10, anticorps sialic acid-binding Ig-like lectin 10, anticorps SIGLEC10, anticorps Siglec10, anticorps LOC484343, anticorps LOC100066644, anticorps siglec10, anticorps LOC100513863, anticorps LOC100340374

Sujet: SIGLEC10 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. SIGLEC10 preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, SIGLEC10 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-653 AC008750.9 90495-91147 c 654-760 DA387605.1 391-497 761-2959 AF301007.1 262-2460 2960-3794 AY358337.1 1930-2764
Alias Symbols: MGC126774, PRO940, SIGLEC-10, SLG2
Protein Interaction Partner: FLNA, PTPN6,
Protein Size: 697

Poids moléculaire: 76 kDa

ID gène: 89790

NCBI Accession: NM_033130, NP_149121

UniProt: Q96LC7