SHC1 anticorps (C-Term)
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- Antigène Voir toutes SHC1 Anticorps
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SHC1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- AEQLRGEPWF HGKLSRREAE ALLQLNGDFL VRESTTTPGQ YVLTGLQSGQ
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against SHC1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human SHC1
- Top Product
- Discover our top product SHC1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 474 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- Autre désignation
- SHC1 (SHC1 Produits)
- Synonymes
- anticorps SHC1, anticorps SHC, anticorps SHCA, anticorps P66shc, anticorps si:dkey-246i14.4, anticorps wu:fc10h03, anticorps shc, anticorps p66shc, anticorps Shc, anticorps ShcA, anticorps p66, anticorps SHC adaptor protein 1, anticorps Shc1p, anticorps squalene--hopene cyclase, anticorps SHC (Src homology 2 domain containing) transforming protein 1, anticorps SHC (Src homology 2 domain containing) transforming protein 1 L homeolog, anticorps src homology 2 domain-containing transforming protein C1, anticorps SHC1, anticorps shc1, anticorps Shc1, anticorps shc1.L
- Sujet
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SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Alias Symbols: FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Protein Interaction Partner: GRB2, Socs5, IGF1R, UBC, EGFR, Hgf, GAB2, GAB1, CBL, ERBB4, ERBB3, ERBB2, NEDD8, ZAP70, DOK1, KRT77, TUBB2B, TUBB, EEF1A1P5, ARAP1, TIMM50, UBASH3B, TUBA1C, PPP1R9B, TUBB6, ATAD3B, TUBA4B, TUBAL3, MYH14, LRRK1, TUBA8, RAB3GAP2, CORO1C, RUVBL2, CCT2, HAX1,
Protein Size: 474 - Poids moléculaire
- 52 kDa
- ID gène
- 6464
- NCBI Accession
- NM_003029, NP_003020
- UniProt
- P29353
- Pathways
- Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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