SIN3B anticorps (Middle Region)

N° du produit ABIN2784243

Détail du produit anti-SIN3B anticorps

Antigène: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cheval, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIN3B est non-conjugé

Application: Western Blotting (WB)

Séquence: LVSDDVCLKV VELYLNEKKR GAAGGNLSSR CVRAARETSY QWKAERCMAD

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rat: 79%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against SIN3B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SIN3B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1162 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SIN3B (ABIN2784243)

Dhanda, Lindberg, Olsson: "The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues." dans: BMC molecular biology, Vol. 9, pp. 8, (2008) (PubMed).

Détails sur SIN3B

Antigène: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Autre désignation: SIN3B (SIN3B Produits)

Synonymes: anticorps fj63d08, anticorps si:dkey-6n6.6, anticorps wu:fj63d08, anticorps 2810430C10Rik, anticorps SIN3 transcription regulator family member B, anticorps SIN3 transcription regulator family member B S homeolog, anticorps transcriptional regulator, SIN3B (yeast), anticorps sin3b, anticorps SIN3B, anticorps sin3b.S, anticorps Sin3b

Sujet: SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also, it interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. The gene is also able to form a complex with FOXK1 which represses transcription
Alias Symbols: KIAA0700
Protein Interaction Partner: SOX2, HDAC1, HDAC2, UBC, ESR1, AR, TFAP4, TP53, SUMO2, KLF16, MORF4L1, MORF4L2, MRGBP, KDM5A, CIITA, NR1D2, COPS2, SMN1, PBX1, REST, ZBTB4, ARID4A, MYT1, MXI1, SAP25, SMARCE1, SMARCB1, SMARCA4, SMARCA2, CBFA2T3, RNF220, ZBTB16, SETDB1, HDAC9, IKZF4, IKZF1
Protein Size: 1162

Poids moléculaire: 133 kDa

ID gène: 23309

NCBI Accession: NM_015260, NP_056075

UniProt: O75182