FZR1 anticorps (N-Term)
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- Antigène Voir toutes FZR1 Anticorps
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FZR1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SSPVSSPSKH GDRFIPSRAG ANWSVNFHRI NENEKSPSQN RKAKDATSDN
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against FZR1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1
- Top Product
- Discover our top product FZR1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 493 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." dans: Molecular pain, Vol. 12, (2016) (PubMed).
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Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." dans: Molecular pain, Vol. 12, (2016) (PubMed).
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- Antigène
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- Autre désignation
- FZR1 (FZR1 Produits)
- Sujet
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FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, KIAA1242
Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB
Protein Size: 493 - Poids moléculaire
- 55 kDa
- ID gène
- 51343
- NCBI Accession
- NM_016263, NP_057347
- UniProt
- Q9UM11
- Pathways
- DNA Replication, Synthesis of DNA
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