TGIF1 anticorps (C-Term)

N° du produit ABIN2784526

Détail du produit anti-TGIF1 anticorps

Antigène: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Lapin, Cheval, Boeuf (Vache), Chien, Porc, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGIF1 est non-conjugé

Application: Western Blotting (WB)

Séquence: GQNTDIQQIA AKNFTDTSLM YPEDTCKSGP STNTQSGLFN TPPPTPPDLN

Homologie: Cow: 93%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 100%, Rat: 86%, Sheep: 93%

Attributs du produit: This is a rabbit polyclonal antibody against TGIF1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human TGIF1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 401 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TGIF1

Antigène: TGIF1 (TGFB-Induced Factor Homeobox 1 (TGIF1))

Autre désignation: TGIF1 (TGIF1 Produits)

Synonymes: anticorps HPE4, anticorps TGIF, anticorps AA959811, anticorps AI462167, anticorps Tgif, anticorps Tfig, anticorps fa06h05, anticorps fb33g11, anticorps zgc:55852, anticorps wu:fa06h05, anticorps wu:fb33g11, anticorps hpe4, anticorps tgif, anticorps tgif1, anticorps TGFB induced factor homeobox 1, anticorps TGFB-induced factor homeobox 1, anticorps TGFB induced factor homeobox 1 S homeolog, anticorps TGIF1, anticorps Tgif1, anticorps tgif1, anticorps tgif1.S

Sujet: TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Alias Symbols: HPE4, MGC39747, MGC5066, TGIF
Protein Interaction Partner: MDFI, CTBP2, CTBP1, APP, PML, ELAVL1, HDAC1, A2M, AR, SIN3A, SMAD3, LRIF1, MED31, MAPK3, SMAD2, MAPK1, JUN, HMGB1, EEF1A1, FOXH1, SMAD1, SDAD1, STK16, MKKS,
Protein Size: 401

Poids moléculaire: 43 kDa

ID gène: 7050

NCBI Accession: NM_170695, NP_733796

UniProt: Q15583

Pathways: Retinoic Acid Receptor Signaling Pathway, Chromatin Binding, Tube Formation