Dynamin 1 anticorps (Middle Region)

N° du produit ABIN2784624

Détail du produit anti-Dynamin 1 anticorps

Antigène: Dynamin 1 (DNM1)

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynamin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PPVDDSWLQV QSVPAGRRSP TSSPTPQRRA PAVPPARPGS RGPAPGPPPA

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against DNM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human DNM1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 851 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Dynamin 1

Antigène: Dynamin 1 (DNM1)

Autre désignation: DNM1 (DNM1 Produits)

Sujet: DNM1 is a member of the dynamin subfamily of GTP-binding proteins. The protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: DNM
Protein Interaction Partner: BIN1, SLA1, UBC, GRB2, AMPH, NCL, FANCD2, IRF2BPL, TBC1D2, NPM3, SNRPA1, SNX9, Fcho2, IQCB1, NCK2, NCK1, Asap1, SH3BP4, DNM1, PTK2B, PIAS1, SUMO1, UBE2I, SRC, ITSN1, SH3GL2, DYRK1A, CDK5, ARRB1, Ap2a1, SH3KBP1, DNM2, ADAM2, UBASH3A, KIAA1377, GRIN1, MED31
Protein Size: 851

Poids moléculaire: 95 kDa

ID gène: 1759

NCBI Accession: NM_004408, NP_004399

UniProt: P39053

Pathways: Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling