COPA anticorps (N-Term)
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- Antigène Voir toutes COPA Anticorps
- COPA (Coatomer Protein Complex, Subunit alpha (COPA))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Cobaye, Saccharomyces cerevisiae, Chévre
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp COPA est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PWILTSLHNG VIQLWDYRMC TLIDKFDEHD GPVRGIDFHK QQPLFVSGGD
- Homologie
- Cow: 100%, Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 93%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against COPA. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human COPA
- Top Product
- Discover our top product COPA Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1224 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth." dans: Human molecular genetics, Vol. 24, Issue 25, pp. 7295-307, (2015) (PubMed).
: "The spinal muscular atrophy disease protein SMN is linked to the Golgi network." dans: PLoS ONE, Vol. 7, Issue 12, pp. e51826, (2013) (PubMed).
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α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth." dans: Human molecular genetics, Vol. 24, Issue 25, pp. 7295-307, (2015) (PubMed).
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- Antigène
- COPA (Coatomer Protein Complex, Subunit alpha (COPA))
- Autre désignation
- COPA (COPA Produits)
- Synonymes
- anticorps COPA, anticorps DDBDRAFT_0189693, anticorps DDBDRAFT_0233797, anticorps DDB_0189693, anticorps DDB_0233797, anticorps DKFZp469O221, anticorps AU040324, anticorps xenin, anticorps HEP-COP, anticorps cb281, anticorps fb13c12, anticorps wu:fb13c12, anticorps coatomer protein complex subunit alpha, anticorps WD40 repeat-containing protein, anticorps Coatomer subunit alpha, anticorps coatomer protein complex, subunit alpha, anticorps coatomer protein complex subunit alpha L homeolog, anticorps COPA, anticorps copA, anticorps cgd8_860, anticorps Chro.80105, anticorps AFUA_3G08840, anticorps copa, anticorps Copa, anticorps copa.L
- Sujet
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In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone.In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
Alias Symbols: FLJ26320, HEP-COP
Protein Interaction Partner: UBC, SUMO2, SMN1, STAU1, NUDCD1, SUMO1, NEDD8, RPA3, RPA2, RPA1, SUZ12, RNF2, COPZ1, DHX38, COPB2, CCT3, TCP1, SEPT2, ARCN1, UBD, VCAM1, ITGA4, COPB1, COPG2, COPG1, COPE, SEPT9, SEC23A, SEC24C, UBXN6, FBXO6, LMAN1, SACM1L, DDX20, TMED10, GEMIN2, COPA, CDK
Protein Size: 1224 - Poids moléculaire
- 135 kDa
- ID gène
- 1314
- NCBI Accession
- NM_004371, NP_004362
- UniProt
- P53621
- Pathways
- Hormone Activity
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