POLR3C anticorps (Middle Region)

N° du produit ABIN2784816

Détail du produit anti-POLR3C anticorps

Antigène: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3C est non-conjugé

Application: Western Blotting (WB)

Séquence: VEAIIASMQA TGAEEAQLQE IEEMITAPER QQLETLKRNV NKLDASEIQV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 90%

Attributs du produit: This is a rabbit polyclonal antibody against POLR3C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human POLR3C

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 534 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur POLR3C

Antigène: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Autre désignation: POLR3C (POLR3C Produits)

Synonymes: anticorps rpc3, anticorps rpc62, anticorps 4933407E01Rik, anticorps RPC3, anticorps RPC62, anticorps zgc:56348, anticorps polymerase (RNA) III (DNA directed) polypeptide C (62kD) S homeolog, anticorps RNA polymerase III subunit C, anticorps polymerase (RNA) III (DNA directed) polypeptide C (62kD), anticorps polymerase (RNA) III (DNA directed) polypeptide C, anticorps polr3c.S, anticorps POLR3C, anticorps polr3c, anticorps Polr3c

Sujet: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Alias Symbols: RPC3, RPC62
Protein Interaction Partner: PNMA5, CEP63, ROPN1, TNR, ROCK1, TRIM27, UBC, VCP, POLR1C, POLR2E, APP, POLR3H, NOC4L, RSL1D1, POLR3A, POLR3G, POLR3F, GTF3C4, POLR3D, TBP, GTF3C3, GTF3C5, GTF3C2, GTF3C1,
Protein Size: 534

Poids moléculaire: 60 kDa

ID gène: 10623

NCBI Accession: NM_006468, NP_006459

UniProt: Q9BUI4