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POLI anticorps (N-Term)

POLI Reactivité: Humain, Rat, Souris, Cheval, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cobaye, Lapin, Saccharomyces cerevisiae WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2784869
  • Antigène Voir toutes POLI Anticorps
    POLI (Polymerase (DNA Directed) iota (POLI))
    Épitope
    • 15
    • 8
    • 8
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 40
    • 25
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris, Cheval, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cobaye, Lapin, Saccharomyces cerevisiae
    Hôte
    • 52
    • 3
    Lapin
    Clonalité
    • 52
    • 3
    Polyclonal
    Conjugué
    • 20
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp POLI est non-conjugé
    Application
    • 27
    • 27
    • 17
    • 13
    • 13
    • 6
    • 4
    • 4
    • 3
    • 3
    Western Blotting (WB)
    Séquence
    PVVERLGFDE NFVDLTEMVE KRLQQLQSDE LSAVTVSGHV YNNQSINLLD
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against POLI. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human POLI
    Top Product
    Discover our top product POLI Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 740 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    POLI (Polymerase (DNA Directed) iota (POLI))
    Autre désignation
    POLI (POLI Produits)
    Synonymes
    anticorps poli, anticorps wu:fc27h11, anticorps zgc:110185, anticorps GB12093, anticorps NV16187, anticorps RAD30B, anticorps RAD3OB, anticorps Rad30b, anticorps DNA polymerase iota, anticorps polymerase (DNA directed) iota, anticorps polymerase (DNA directed), iota, anticorps POLI, anticorps poli, anticorps LOC551219, anticorps AFUA_4G11140, anticorps LOC5568276, anticorps Pol-iota, anticorps Poli
    Sujet
    POLI is an error-prone DNA polymerase specifically involved in DNA repair.POLI plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls.POLI favors Hoogsteen base-pairing in the active site.POLI inserts the correct base with high-fidelity opposite an adenosine template.POLI exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine.POLI may play a role in hypermutation of immunogobulin genes.POLI forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
    Alias Symbols: RAD30B, RAD3OB
    Protein Interaction Partner: TMEM239, TRIM39, ZBTB44, UBC, TRAF6, DAZAP2, RNF11, TRIM23, POLH, PCNA, APP, REV1, XRCC1, UBB, UBA52, CALCOCO2, DVL2,
    Protein Size: 740
    Poids moléculaire
    83 kDa
    ID gène
    11201
    NCBI Accession
    NM_007195, NP_009126
    UniProt
    Q9UNA4
    Pathways
    Réparation de l'ADN
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