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CAPN10 anticorps (N-Term)

CAPN10 Reactivité: Humain, Souris, Chien, Lapin, Cobaye, Rat, Boeuf (Vache) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2784913
  • Antigène Voir toutes CAPN10 Anticorps
    CAPN10 (Calpain 10 (CAPN10))
    Épitope
    • 3
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 16
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Chien, Lapin, Cobaye, Rat, Boeuf (Vache)
    Hôte
    • 17
    Lapin
    Clonalité
    • 17
    Polyclonal
    Conjugué
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CAPN10 est non-conjugé
    Application
    • 10
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    MRAGRGATPA RELFRDAAFP AADSSLFCDL STPLAQFRED ITWRRPQEIC
    Homologie
    Cow: 92%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%
    Attributs du produit
    This is a rabbit polyclonal antibody against CAPN10. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human CAPN10
    Top Product
    Discover our top product CAPN10 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 517 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    CAPN10 (Calpain 10 (CAPN10))
    Autre désignation
    CAPN10 (CAPN10 Produits)
    Synonymes
    anticorps CAPN10, anticorps CANP10, anticorps NIDDM1, anticorps AW049679, anticorps Capn8, anticorps mKIAA1845, anticorps calpain 10, anticorps calpain 10 L homeolog, anticorps CAPN10, anticorps capn10.L, anticorps capn10, anticorps Capn10
    Sujet
    CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation, domain II, the protease domain, domain III, a linker domain of unknown function, and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
    Alias Symbols: CANP10, NIDDM1
    Protein Interaction Partner: EFNB1, FLOT1, PSMA7, FANCC,
    Protein Size: 517
    Poids moléculaire
    58 kDa
    ID gène
    11132
    NCBI Accession
    NM_023085, NP_075573
    UniProt
    Q9HC96
    Pathways
    Positive Regulation of Peptide Hormone Secretion
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