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CHMP4B anticorps (Middle Region)

CHMP4B Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2785348
  • Antigène Voir toutes CHMP4B Anticorps
    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
    Épitope
    • 15
    • 8
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    Middle Region
    Reactivité
    • 44
    • 21
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)
    Hôte
    • 43
    • 1
    Lapin
    Clonalité
    • 43
    • 1
    Polyclonal
    Conjugué
    • 13
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CHMP4B est non-conjugé
    Application
    • 19
    • 19
    • 18
    • 13
    • 13
    • 12
    • 5
    • 3
    • 3
    • 3
    Western Blotting (WB)
    Séquence
    EEISTAISKP VGFGEEFDED ELMAELEELE QEELDKNLLE ISGPETVPLP
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against CHMP4B. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human CHMP4B
    Top Product
    Discover our top product CHMP4B Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 224 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Bodon, Chassefeyre, Pernet-Gallay, Martinelli, Effantin, Hulsik, Belly, Goldberg, Chatellard-Causse, Blot, Schoehn, Weissenhorn, Sadoul: "Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane." dans: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40276-86, (2011) (PubMed).

  • Antigène
    CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
    Autre désignation
    CHMP4B (CHMP4B Produits)
    Synonymes
    anticorps C20orf178, anticorps CHMP4A, anticorps CTPP3, anticorps CTRCT31, anticorps SNF7, anticorps SNF7-2, anticorps Shax1, anticorps VPS32B, anticorps Vps32-2, anticorps dJ553F4.4, anticorps 2010012F05Rik, anticorps C76846, anticorps Snf7-2, anticorps RGD1309846, anticorps RGD1565889, anticorps CHMP4b, anticorps chmp4b, anticorps chmp4b.S, anticorps CHMP4c, anticorps c20orf178, anticorps wu:fc96b02, anticorps zgc:55566, anticorps charged multivesicular body protein 4B, anticorps charged multivesicular body protein 4Ba, anticorps charged multivesicular body protein 4B L homeolog, anticorps charged multivesicular body protein 4Bb, anticorps CHMP4B, anticorps Chmp4b, anticorps chmp4ba, anticorps chmp4b.L, anticorps chmp4bb
    Sujet
    This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
    Alias Symbols: C20orf178, CHMP4A, CTPP3, SNF7, SNF7-2, Shax1, dJ553F4.4, VPS32B, Vps32-2
    Protein Interaction Partner: UBC, TP53, CHMP6, UBE2I, PDCD6IP, VCAM1, ITGA4, RPLP0P6, MVP, ATP6V1B1, BROX, CHMP4B, CHMP4C, CHMP1B, CHMP3, CHMP5, CHMP4A, HIPK2, VPS4A, STAMBP, PIAS2, EXOSC9, HCVgp1, NOLC1, PTPN23,
    Protein Size: 224
    Poids moléculaire
    25 kDa
    ID gène
    128866
    NCBI Accession
    NM_176812, NP_789782
    UniProt
    Q9H444
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