CHMP4B anticorps (Middle Region)

N° du produit ABIN2785348

Détail du produit anti-CHMP4B anticorps

Antigène: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Cheval, Poisson zèbre (Danio rerio), Boeuf (Vache), Lapin, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP4B est non-conjugé

Application: Western Blotting (WB)

Séquence: EEISTAISKP VGFGEEFDED ELMAELEELE QEELDKNLLE ISGPETVPLP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CHMP4B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CHMP4B

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 224 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CHMP4B (ABIN2785348)

Bodon, Chassefeyre, Pernet-Gallay, Martinelli, Effantin, Hulsik, Belly, Goldberg, Chatellard-Causse, Blot, Schoehn, Weissenhorn, Sadoul: "Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane." dans: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40276-86, (2011) (PubMed).

Détails sur CHMP4B

Antigène: CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))

Autre désignation: CHMP4B (CHMP4B Produits)

Synonymes: anticorps C20orf178, anticorps CHMP4A, anticorps CTPP3, anticorps CTRCT31, anticorps SNF7, anticorps SNF7-2, anticorps Shax1, anticorps VPS32B, anticorps Vps32-2, anticorps dJ553F4.4, anticorps 2010012F05Rik, anticorps C76846, anticorps Snf7-2, anticorps RGD1309846, anticorps RGD1565889, anticorps CHMP4b, anticorps chmp4b, anticorps chmp4b.S, anticorps CHMP4c, anticorps c20orf178, anticorps wu:fc96b02, anticorps zgc:55566, anticorps charged multivesicular body protein 4B, anticorps charged multivesicular body protein 4Ba, anticorps charged multivesicular body protein 4B L homeolog, anticorps charged multivesicular body protein 4Bb, anticorps CHMP4B, anticorps Chmp4b, anticorps chmp4ba, anticorps chmp4b.L, anticorps chmp4bb

Sujet: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Alias Symbols: C20orf178, CHMP4A, CTPP3, SNF7, SNF7-2, Shax1, dJ553F4.4, VPS32B, Vps32-2
Protein Interaction Partner: UBC, TP53, CHMP6, UBE2I, PDCD6IP, VCAM1, ITGA4, RPLP0P6, MVP, ATP6V1B1, BROX, CHMP4B, CHMP4C, CHMP1B, CHMP3, CHMP5, CHMP4A, HIPK2, VPS4A, STAMBP, PIAS2, EXOSC9, HCVgp1, NOLC1, PTPN23,
Protein Size: 224

Poids moléculaire: 25 kDa

ID gène: 128866

NCBI Accession: NM_176812, NP_789782

UniProt: Q9H444