SPAG6 anticorps (Middle Region)

N° du produit ABIN2785513

Détail du produit anti-SPAG6 anticorps

Antigène: SPAG6 (Sperm Associated Antigen 6 (SPAG6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPAG6 est non-conjugé

Application: Western Blotting (WB)

Séquence: HVVGQFSKVL PHDSKARRLF VTSGGLKKVQ EIKAEPGSLL QEYINSINSC

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SPAG6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SPAG6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 509 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SPAG6 (ABIN2785513)

Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: "The LIFEdb database in 2006." dans: Nucleic acids research, Vol. 34, Issue Database issue, pp. D415-8, (2005) (PubMed).

Détails sur SPAG6

Antigène: SPAG6 (Sperm Associated Antigen 6 (SPAG6))

Autre désignation: SPAG6 (SPAG6 Produits)

Synonymes: anticorps Repro-SA-1, anticorps pf16, anticorps PF16, anticorps RGD1310892, anticorps zgc:91805, anticorps SPAG6, anticorps repro-sa-1, anticorps DKFZp459D035, anticorps sperm associated antigen 6, anticorps sperm associated antigen 6-like, anticorps sperm associated antigen 6 L homeolog, anticorps SPAG6, anticorps Spag6l, anticorps Spag6, anticorps spag6, anticorps spag6.L

Sujet: SPAG6 is important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
Alias Symbols: DKFZp434I153, MGC26276, Repro-SA-1, pf16
Protein Interaction Partner: APP, SPAG16,
Protein Size: 509

Poids moléculaire: 56 kDa

ID gène: 9576

NCBI Accession: NM_012443, NP_036575

UniProt: O75602