SOCS7 anticorps (N-Term)
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- Antigène Voir toutes SOCS7 Anticorps
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SOCS7 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LDPKALPPGL ALERTWGPAA GLEAQLAALG LGQPAGPGVK TVGGGCCPCP
- Homologie
- Cow: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against SOCS7. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human SOCS7
- Top Product
- Discover our top product SOCS7 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 581 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
- Autre désignation
- SOCS7 (SOCS7 Produits)
- Synonymes
- anticorps NAP4, anticorps NCKAP4, anticorps SOCS4, anticorps SOCS6, anticorps 2310063P06Rik, anticorps C85125, anticorps Nap4, anticorps GB13951, anticorps zgc:175115, anticorps SOCS7, anticorps socs7, anticorps suppressor of cytokine signaling 7, anticorps suppressor of cytokine signaling, anticorps SOCS7, anticorps Socs7, anticorps LOC413772, anticorps socs7
- Sujet
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SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: SEPT6, SORBS3, STAT5A, STAT3, CUL5, IRS4, PIK3R2, TUBB4B, TUBA1A, IRS2, NCK1, PLCG1, PIK3R1, EGFR, GRB2,
Protein Size: 581 - Poids moléculaire
- 64 kDa
- ID gène
- 30837
- NCBI Accession
- NM_014598, NP_055413
- UniProt
- O14512
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