GCAP1 anticorps (N-Term)
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- Antigène Voir toutes GCAP1 (GUCA1A) Anticorps
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
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Épitope
- N-Term
- Reactivité
- Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Porc, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GCAP1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LYEFRQFFGL KNLSPSASQY VEQMFETFDF NKDGYIDFME YVAALSLVLK
- Homologie
- Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against GUCA1A. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human GUCA1A
- Top Product
- Discover our top product GUCA1A Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 201 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
- Autre désignation
- GUCA1A (GUCA1A Produits)
- Synonymes
- anticorps C6orf131, anticorps COD3, anticorps CORD14, anticorps GCAP, anticorps GCAP1, anticorps GUCA, anticorps GUCA1, anticorps dJ139D8.6, anticorps MGC84170, anticorps GUCA1A, anticorps guca1a, anticorps MGC146317, anticorps GC-A, anticorps Gcap1, anticorps Guca1, anticorps mGCAP1, anticorps gcap1, anticorps guanylate cyclase activator 1A, anticorps guanylate cyclase activator 1A L homeolog, anticorps guanylate cyclase activator 1A (retina), anticorps guanylate cyclase activator 1a (retina), anticorps GUCA1A, anticorps Guca1a, anticorps guca1a.L, anticorps guca1a
- Sujet
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GUCA1A(GCAP1) plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3), a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations, causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia.
Alias Symbols: COD3, GCAP, GCAP1, GUCA, GUCA1, CORD14, C6orf131, dJ139D8.6
Protein Interaction Partner: GUCY2D,
Protein Size: 201 - Poids moléculaire
- 23 kDa
- ID gène
- 2978
- NCBI Accession
- NM_000409, NP_000400
- UniProt
- P43080
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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