IL1A anticorps (N-Term)
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- Antigène Voir toutes IL1A Anticorps
- IL1A (Interleukin 1 alpha (IL1A))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Cheval, Chévre, Chien, Boeuf (Vache), Mouton
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IL1A est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- VSYGPLHEGC MDQSVSLSIS ETSKTSKLTF KESMVVVATN GKVLKKRRLS
- Homologie
- Cow: 92%, Dog: 85%, Goat: 85%, Horse: 93%, Human: 100%, Mouse: 79%, Rat: 79%, Sheep: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against IL1A. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human IL1A
- Top Product
- Discover our top product IL1A Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 271 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." dans: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).
: "Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1?, controlling necrosis-induced sterile inflammation." dans: Immunity, Vol. 38, Issue 2, pp. 285-95, (2013) (PubMed).
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Shigella flexneri T3SS effector IpaH4.5 modulates the host inflammatory response via interaction with NF-?B p65 protein." dans: Cellular microbiology, Vol. 15, Issue 3, pp. 474-85, (2013) (PubMed).
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- Antigène
- IL1A (Interleukin 1 alpha (IL1A))
- Autre désignation
- IL1A (IL1A Produits)
- Synonymes
- anticorps IL-1A, anticorps IL1, anticorps IL1-ALPHA, anticorps IL1F1, anticorps IL-6, anticorps Il-1a, anticorps IL-1 alpha, anticorps IL-1alpha, anticorps L1A, anticorps interleukin 1 alpha, anticorps interleukin 6, anticorps IL1A, anticorps IL6, anticorps Il1a
- Sujet
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The IL1A protein is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. The gene encoding IL1A and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IL-1A, IL1, IL1-ALPHA, IL1F1
Protein Interaction Partner: HFI1, AHC1, GCN5, SPT7, ADA2, NGG1, SPT8, HAX1, NFKBIE, IL1RAP, NDN, S100A13, IL1R2, IL1R1, IL1A, CAPN1,
Protein Size: 271 - Poids moléculaire
- 18 kDa
- ID gène
- 3552
- NCBI Accession
- NM_000575, NP_000566
- UniProt
- P01583
- Pathways
- Signalisation NF-kappaB, Autophagy, Cancer Immune Checkpoints
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