GALE anticorps (Middle Region)

N° du produit ABIN2785691

Détail du produit anti-GALE anticorps

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Épitope: Middle Region

Reactivité: Humain, Rat, Chien, Porc, Lapin, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GALE est non-conjugé

Application: Western Blotting (WB)

Séquence: PQGIPNNLMP YVSQVAIGRR EALNVFGNDY DTEDGTGVRD YIHVVDLAKG

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against GALE. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GALE

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 348 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GALE

Antigène: GALE (UDP-Galactose-4-Epimerase (GALE))

Autre désignation: GALE (GALE Produits)

Synonymes: anticorps GALE, anticorps im:7147391, anticorps wu:fb05f01, anticorps zgc:136578, anticorps F15H21.11, anticorps F15H21_11, anticorps REB1, anticorps ROOT EPIDERMAL BULGER1, anticorps ROOT HAIR DEFECTIVE 1, anticorps UDP-GLUCOSE 4-EPIMERASE, anticorps UGE4, anticorps ECK0748, anticorps galD, anticorps JW0742, anticorps SMU.888, anticorps BA5505, anticorps BA5700, anticorps VFA0352, anticorps galE, anticorps 2310002A12Rik, anticorps AI323962, anticorps 1n569, anticorps xgale, anticorps SDR1E1, anticorps UDP-galactose-4-epimerase, anticorps NAD(P)-binding Rossmann-fold superfamily protein, anticorps UDP-galactose 4-epimerase GalE, anticorps UDP-glucose 4-epimerase, anticorps UDP-glucose 4-epimerase GalE, anticorps UDP-glucose/UDP-N-acetylglucosamine 4-epimerase, anticorps galactose-4-epimerase, UDP, anticorps UDP-galactose-4-epimerase L homeolog, anticorps GALE, anticorps gale, anticorps RHD1, anticorps ECs0787, anticorps galE, anticorps galE1, anticorps galE2, anticorps STY0809, anticorps galE-2, anticorps SG0897, anticorps galD, anticorps Ent638_1250, anticorps Gale, anticorps gale.L

Sujet: GALE is an UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form).
Alias Symbols: SDR1E1
Protein Interaction Partner: GALE, SUMO2, UBC, BAG3, FN1, APP,
Protein Size: 348

Poids moléculaire: 38 kDa

ID gène: 2582

NCBI Accession: NM_001008216, NP_001008217

UniProt: Q14376

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process