GCLC anticorps (Middle Region)
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- Antigène Voir toutes GCLC Anticorps
- GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Lapin, Chien, Cobaye, Cheval, Saccharomyces cerevisiae
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GCLC est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- RISKSRYDSI DSYLSKCGEK YNDIDLTIDK EIYEQLLQEG IDHLLAQHVA
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against GCLC. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human GCLC
- Top Product
- Discover our top product GCLC Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 637 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." dans: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).
: "Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease." dans: Experimental and molecular pathology, Vol. 90, Issue 1, pp. 123-30, (2011) (PubMed).
: "
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Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." dans: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).
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- Antigène
- GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
- Autre désignation
- GCLC (GCLC Produits)
- Synonymes
- anticorps GCLC, anticorps gclc, anticorps MGC146287, anticorps 2259, anticorps CG2259, anticorps DmGCLC, anticorps DmGCS, anticorps DmGCSh, anticorps Dmel\\CG2259, anticorps GCL, anticorps GCLc, anticorps GCSh, anticorps Gcs, anticorps Gcsh, anticorps DDBDRAFT_0186120, anticorps DDBDRAFT_0231403, anticorps DDB_0186120, anticorps DDB_0231403, anticorps GCS, anticorps GLCL, anticorps GLCLC, anticorps D9Wsu168e, anticorps GLCL-H, anticorps Ggcs-hs, anticorps Glclc, anticorps cb1049, anticorps fe36e11, anticorps wu:fe36e11, anticorps glutamate-cysteine ligase catalytic subunit, anticorps glutamate-cysteine ligase, catalytic subunit, anticorps Glutamate-cysteine ligase catalytic subunit, anticorps gamma glutamylcysteine synthetase, anticorps glutamate-cysteine ligase, catalytic subunit L homeolog, anticorps glutamate-cysteine ligase, catalytic subunit S homeolog, anticorps gamma-glutamylcysteine synthetase, anticorps GCLC, anticorps gclc, anticorps Gclc, anticorps LbGCS, anticorps gcsA, anticorps gclc.L, anticorps gclc.S, anticorps GSH1
- Sujet
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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. GCLC is the catalytic subunit of 637 amino acids with a calculated molecular weight of 72.773 kDa. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.
Alias Symbols: GCL, GCS, GLCL, GLCLC
Protein Interaction Partner: UBC, PPID, GCLM, CCL22, PAXIP1, ELAVL1,
Protein Size: 637 - Poids moléculaire
- 73 kDa
- ID gène
- 2729
- NCBI Accession
- NM_001498, NP_001489
- UniProt
- P48506
- Pathways
- Cell RedoxHomeostasis
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