GLE1 anticorps (N-Term)

N° du produit ABIN2785781

Détail du produit anti-GLE1 anticorps

Antigène: GLE1 (GLE1 RNA Export Mediator (GLE1))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Cheval, Boeuf (Vache), Chien, Porc, Lapin, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLE1 est non-conjugé

Application: Western Blotting (WB)

Séquence: LKLREAEQQR VKQAEQERLR KEEGQIRLRA LYALQEEMLQ LSQQLDASEQ

Homologie: Cow: 93%, Dog: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 77%, Rat: 100%, Yeast: 90%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against GLE1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human GLE1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 659 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GLE1

Antigène: GLE1 (GLE1 RNA Export Mediator (GLE1))

Autre désignation: GLE1 (GLE1 Produits)

Synonymes: anticorps Dmel\\CG14749, anticorps GLE1, anticorps GLE1L, anticorps LCCS, anticorps LCCS1, anticorps hGLE1, anticorps Gle1l, anticorps 4933405K21Rik, anticorps AA553313, anticorps CG14749 gene product from transcript CG14749-RA, anticorps nucleoporin GLE1, anticorps RNA export factor Gle1, anticorps GLE1, RNA export mediator, anticorps GLE1 RNA export mediator, anticorps GLE1 RNA export mediator (yeast), anticorps CG14749, anticorps CpipJ_CPIJ014147, anticorps SJAG_03847, anticorps GLE1, anticorps Gle1

Sujet: GLE1 is a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm.This gene encodes a predicted 75- kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: GLE1L, hGLE1, LCCS, LCCS1
Protein Interaction Partner: RNF2, UBC, ELAVL1, NUPL2, NUP155, EIF3F, UXT, KRT10,
Protein Size: 659

Poids moléculaire: 75 kDa

ID gène: 2733

NCBI Accession: NM_001499, NP_001490

UniProt: Q53GS7