KPNA1 anticorps (N-Term)

N° du produit ABIN2785822

Détail du produit anti-KPNA1 anticorps

Antigène: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA1 est non-conjugé

Application: Western Blotting (WB)

Séquence: TTPGKENFRL KSYKNKSLNP DEMRRRREEE GLQLRKQKRE EQLFKRRNVA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KPNA1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human KPNA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 538 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KPNA1 (ABIN2785822)

Theodore, Kawai, Yang, Kleshchenko, Reddy, Villalta, Arinze: "Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2." dans: The Journal of biological chemistry, Vol. 283, Issue 14, pp. 8984-94, (2008) (PubMed).

Détails sur KPNA1

Antigène: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Autre désignation: KPNA1 (KPNA1 Produits)

Synonymes: anticorps IPOA5, anticorps NPI-1, anticorps RCH2, anticorps SRP1, anticorps AW494490, anticorps NPI1, anticorps Rch2, anticorps mSRP1, anticorps si:ch211-161h7.7, anticorps karyopherin subunit alpha 1, anticorps importin alpha-1 subunit, anticorps karyopherin (importin) alpha 1, anticorps karyopherin alpha 1 (importin alpha 5), anticorps KPNA1, anticorps Kpna1, anticorps EHI_124900, anticorps kpna1

Sujet: Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. KPNA1 interacts with RAG1 and may play a role in V(D)J recombination.Recombination activating proteins RAG1 and RAG2 regulate and mediate V(D)J recombination, the process by which genes for immunoglobulins and T-cell receptors are generated. Several other ubiquitously expressed proteins are thought to be recruited in the recombination process. Among these are the genes affected in severe combined immune deficiency and genes involved in ds-DNA break repair. The protein encoded by this gene interacts with RAG1 and may play a role in V(D)J recombination. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IPOA5, NPI-1, RCH2, SRP1
Protein Interaction Partner: UBC, TAF9, CLK4, NUP50, ANP32B, XRN2, rev, TRMT61A, KCTD12, NPM1, GABPA, DCAF6, LIMCH1, HECW2, CLK3, HDAC2, HDAC1, GOPC, HDAC6, CRADD, LMO4, BCAR3, FOSL1, SKP2, ORC4, IL1RAP, AICDA, TP53BP1, KPNB1, RAG1, NOSIP, DCAF8, ANP32A, CAND1, COPS5, CUL1, CUL3, CUL
Protein Size: 538

Poids moléculaire: 60 kDa

ID gène: 3836

NCBI Accession: NM_002264, NP_002255

UniProt: P52294

Pathways: M Phase, Protein targeting to Nucleus