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Sphingomyelin Synthase 1 anticorps (Middle Region)

SGMS1 Reactivité: Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien, Cobaye, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2786225
  • Antigène Voir toutes Sphingomyelin Synthase 1 (SGMS1) Anticorps
    Sphingomyelin Synthase 1 (SGMS1)
    Épitope
    • 15
    • 8
    • 8
    • 6
    • 5
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 27
    • 20
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien, Cobaye, Poisson zèbre (Danio rerio)
    Hôte
    • 42
    Lapin
    Clonalité
    • 42
    Polyclonal
    Conjugué
    • 14
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Sphingomyelin Synthase 1 est non-conjugé
    Application
    • 38
    • 20
    • 15
    • 13
    • 13
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    LTTVMISVVH ERVPPKEVQP PLPDTFFDHF NRVQWAFSIC EINGMILVGL
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
    Attributs du produit
    This is a rabbit polyclonal antibody against Sgms1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of Mouse Sgms1
    Top Product
    Discover our top product SGMS1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 419 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Miyamoto, Hsu, Hamm, Darshi, Diamond-Stanic, Declèves, Slater, Pennathur, Stauber, Dorrestein, Sharma: "Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator." dans: EBioMedicine, Vol. 7, pp. 121-34, (2016) (PubMed).

  • Antigène
    Sphingomyelin Synthase 1 (SGMS1)
    Autre désignation
    Sgms1 (SGMS1 Produits)
    Synonymes
    anticorps MGC81436, anticorps TMEM23, anticorps MOB, anticorps MOB1, anticorps SMS1, anticorps hmob33, anticorps 9530058O11Rik, anticorps AI841905, anticorps C80702, anticorps Mob, anticorps Sms1, anticorps Sor1, anticorps Tmem23, anticorps sphingomyelin synthase 1, anticorps sphingomyelin synthase 1 S homeolog, anticorps phosphatidylcholine:ceramide cholinephosphotransferase 1, anticorps SGMS1, anticorps sgms1.S, anticorps LOC100013212, anticorps Sgms1
    Sujet
    Bidirectional lipid cholinephosphotransferase is capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Sgms1 directly and specifically recognizes the choline head group on the substrate. It also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Sgms1 does not function strictly as a SM synthase and suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. Sgms1 may protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.
    Alias Symbols: 9530058O11Rik, AI841905, C80702, MGC30540, Mob, Sms1, Sor1, Tmem23
    Protein Size: 419
    Poids moléculaire
    46 kDa
    ID gène
    208449
    NCBI Accession
    NM_144792, NP_659041
    UniProt
    Q8VCQ6
    Pathways
    Cellular Response to Molecule of Bacterial Origin
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