FBXW8 anticorps (Middle Region)

N° du produit ABIN2786275

Détail du produit anti-FBXW8 anticorps

Antigène: FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Cobaye, Cheval, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXW8 est non-conjugé

Application: Western Blotting (WB)

Séquence: MNQKLWEVYS GHPVQHISFS SHSLITANVP YQTVMRNADL DSFTTHRRHR

Homologie: Cow: 83%, Dog: 92%, Guinea Pig: 83%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against FBXW8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human FBXW8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 598 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FBXW8 (ABIN2786275)

Lin, Fu, Zhao, Lin, Zou, Liu, Zhu, Wang, Yu: "Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells." dans: Molecular biology reports, Vol. 38, Issue 3, pp. 1741-7, (2011) (PubMed).

Détails sur FBXW8

Antigène: FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))

Autre désignation: FBXW8 (FBXW8 Produits)

Synonymes: anticorps FBW6, anticorps FBW8, anticorps FBX29, anticorps FBXO29, anticorps FBXW6, anticorps 4930438M06Rik, anticorps Fbx29, anticorps F-box and WD repeat domain containing 8, anticorps ring finger protein, transmembrane 2, anticorps F-box and WD-40 domain protein 8, anticorps FBXW8, anticorps Fbxw8, anticorps RNFT2

Sujet: FBXW8 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXW8 contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class.This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
Alias Symbols: FBW6, FBW8, FBX29, FBXO29, MGC33534, FBXW6
Protein Interaction Partner: MAP4K1, CUL1, TBC1D3, CUL7, UBE2D3, SKP1, IRS1, REST, CCND1, CUL4A, DDB1, UBC, CCDC8, GORASP1, OBSL1, CCT6B, CCT2, CCT7, TRIP13, PDCD5, CUL2, VBP1, CCT3, PFDN5, NFKBIA, CCT6A, BCL3, BTRC, SKP2, HSP90AA1, HSPA4, FBXO4, FBXW8, FBXW2, MYC, RBX1, UBI4, EP300,
Protein Size: 598

Poids moléculaire: 67 kDa

ID gène: 26259

NCBI Accession: NM_153348, NP_699179

UniProt: Q8N3Y1