PRAME anticorps (N-Term)
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- Antigène Voir toutes PRAME Anticorps
- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Cheval, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PRAME est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MERRRLWGSI QSRYISMSVW TSPRRLVELA GQSLLKDEAL AIAALELLPR
- Homologie
- Cow: 86%, Horse: 93%, Human: 100%, Mouse: 79%, Pig: 86%, Rat: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against PRAME. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human PRAME
- Top Product
- Discover our top product PRAME Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 509 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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A novel testis-specific protein, PRAMEY, is involved in spermatogenesis in cattle." dans: Reproduction (Cambridge, England), Vol. 153, Issue 6, pp. 847-863, (2017) (PubMed).
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A novel testis-specific protein, PRAMEY, is involved in spermatogenesis in cattle." dans: Reproduction (Cambridge, England), Vol. 153, Issue 6, pp. 847-863, (2017) (PubMed).
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- Antigène
- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
- Autre désignation
- PRAME (PRAME Produits)
- Sujet
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PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alias Symbols: MAPE, OIP4, CT130
Protein Interaction Partner: PRAME, RBX1, CUL2, TCEB2, TCEB1, ZNF408, FBXL12, XRN2, HIST4H4, HIST2H2BE, HIST2H2AC, HIST3H3, UBC, RARA, TP53RK, OSGEP, TPRKB, KDM1A, BAG2, LAGE3, UBL4A, SNRPB, RPS13, RPL22, RPL10, RFC4, PSMC4, HNRNPM, HNRNPH1, HNRNPF, HNRNPC, NEDD8, STK19,
Protein Size: 509 - Poids moléculaire
- 56 kDa
- ID gène
- 23532
- NCBI Accession
- NM_006115, NP_006106
- UniProt
- P78395
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
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