Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

AKTIP anticorps (Middle Region)

AKTIP Reactivité: Humain, Souris, Rat, Chien, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2786570
  • Antigène Voir toutes AKTIP Anticorps
    AKTIP (AKT Interacting Protein (AKTIP))
    Épitope
    • 30
    • 11
    • 8
    • 8
    • 6
    • 1
    • 1
    Middle Region
    Reactivité
    • 34
    • 30
    • 23
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval
    Hôte
    • 58
    • 6
    Lapin
    Clonalité
    • 61
    • 3
    Polyclonal
    Conjugué
    • 16
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp AKTIP est non-conjugé
    Application
    • 53
    • 26
    • 26
    • 26
    • 6
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 83%
    Attributs du produit
    This is a rabbit polyclonal antibody against AKTIP. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human AKTIP
    Top Product
    Discover our top product AKTIP Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 292 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

  • Antigène
    AKTIP (AKT Interacting Protein (AKTIP))
    Autre désignation
    AKTIP (AKTIP Produits)
    Synonymes
    anticorps FT1, anticorps FTS, anticorps cb798, anticorps fts, anticorps zgc:77699, anticorps fts-A, anticorps aktip, anticorps fts-B, anticorps MGC133931, anticorps AL023020, anticorps Fif, anticorps Ft, anticorps Ft1, anticorps Fts, anticorps AKT interacting protein, anticorps akt interacting protein, anticorps AKT interacting protein L homeolog, anticorps AKT interacting protein S homeolog, anticorps thymoma viral proto-oncogene 1 interacting protein, anticorps AKTIP, anticorps aktip, anticorps aktip.L, anticorps aktip.S, anticorps Aktip
    Sujet
    AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
    Alias Symbols: FT1, FTS
    Protein Interaction Partner: HOOK1, HOOK2, HOOK3, FAM160A2, VPS16, VPS18, VPS41, TRIM23, TRIM41, MARCH5, DZIP3, KIAA1377, EXOC7, POLA2, GTF3C1, UTP14A, C10orf2, PDPK1, ASS1, CTBP2, IMMT, RPA1, AKT1, TIMM50, PDS5A, IARS, HDLBP, DCTN1,
    Protein Size: 292
    Poids moléculaire
    33 kDa
    ID gène
    64400
    NCBI Accession
    NM_001012398, NP_001012398
    UniProt
    Q9H8T0
Vous êtes ici:
Support technique