PKC iota anticorps (Middle Region)

N° du produit ABIN2786697

Cet anticorps Lapin Polyclonal détecte spécifiquement PKC iota dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour PKC iota anticorps (Middle Region) (ABIN2786697)

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKC iota est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PKC iota anticorps

Épitope: Middle Region

Séquence: TVIPYNPSSH ESLDQVGEEK EAMNTRESGK ASSSLGLQDF DLLRVIGRGS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PRKCI. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRKCI

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 596 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PKC iota

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Autre désignation: PRKCI

Sujet: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Alias Symbols: DXS1179E, MGC26534, PKCI, nPKC-iota
Protein Interaction Partner: PARD6B, PARD6A, UBC, AMOT, SQSTM1, CRX, NPM1, IKBKG, YWHAE, IL1RAP, HSP90AA1, GAB1, CASP8, PARD3, APP, UBD, MAP2K5, MARK2, ARHGAP17, TJP1, ELAVL1, CDK7, MBP, TSC22D1, TTR, FABP4, PARD6G, MARK4, CDC37, RAPGEF2, PNMA1, NIPSNAP1, YWHAZ, YWHAH, MYO10, LLGL1,
Protein Size: 596

Poids moléculaire: 68 kDa

ID gène: 5584

NCBI Accession: NM_002740, NP_002731

UniProt: P41743

Pathways: Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation