PKC iota anticorps (Middle Region)

N° du produit ABIN2786697

Détail du produit anti-PKC iota anticorps

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKC iota est non-conjugé

Application: Western Blotting (WB)

Séquence: TVIPYNPSSH ESLDQVGEEK EAMNTRESGK ASSSLGLQDF DLLRVIGRGS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PRKCI. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRKCI

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 596 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PKC iota

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Autre désignation: PRKCI (PRKCI Produits)

Synonymes: anticorps DXS1179E, anticorps PKCI, anticorps nPKC-iota, anticorps aPKC[l], anticorps hal, anticorps has, anticorps PRKCI, anticorps PKC, anticorps 2310021H13Rik, anticorps AI427505, anticorps PKClambda, anticorps Pkci, anticorps Pkcl, anticorps Prkcl, anticorps aPKClambda, anticorps mKIAA4165, anticorps protein kinase C iota, anticorps protein kinase C, iota, anticorps PRKCI, anticorps prkci, anticorps Prkci

Sujet: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.
Alias Symbols: DXS1179E, MGC26534, PKCI, nPKC-iota
Protein Interaction Partner: PARD6B, PARD6A, UBC, AMOT, SQSTM1, CRX, NPM1, IKBKG, YWHAE, IL1RAP, HSP90AA1, GAB1, CASP8, PARD3, APP, UBD, MAP2K5, MARK2, ARHGAP17, TJP1, ELAVL1, CDK7, MBP, TSC22D1, TTR, FABP4, PARD6G, MARK4, CDC37, RAPGEF2, PNMA1, NIPSNAP1, YWHAZ, YWHAH, MYO10, LLGL1,
Protein Size: 596

Poids moléculaire: 68 kDa

ID gène: 5584

NCBI Accession: NM_002740, NP_002731

UniProt: P41743

Pathways: Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation