Nemo-Like Kinase anticorps (Middle Region)
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- Antigène Voir toutes Nemo-Like Kinase (NLK) Anticorps
- Nemo-Like Kinase (NLK)
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Épitope
- Middle Region
- Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Nemo-Like Kinase est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- RLRYHTCMCK CCFSTSTGRV YTSDFEPVTN PKFDDTFEKN LSSVRQVKEI
- Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against NLK. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human NLK
- Top Product
- Discover our top product NLK Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 527 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Nemo-Like Kinase (NLK)
- Autre désignation
- NLK (NLK Produits)
- Synonymes
- anticorps Amf, anticorps Gpi1, anticorps AI194375, anticorps nlk, anticorps nlkb, anticorps zgc:111875, anticorps Xnlk, anticorps nlk1, anticorps nlk2, anticorps NLK, anticorps nemo-like, anticorps RGD1561602, anticorps glucose-6-phosphate isomerase, anticorps nemo like kinase, anticorps nemo-like kinase, type 1, anticorps nemo-like kinase L homeolog, anticorps Nemo-Like kinase, anticorps nemo-like kinase, anticorps Gpi, anticorps NLK, anticorps Nlk, anticorps nlk1, anticorps nlk.L, anticorps nlk, anticorps nemo-like
- Sujet
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NLK has a role in cell fate determination, required for differentiation of bone marrow stromal cells. NLK acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. NLK may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP By similarity.NLK is involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
Alias Symbols: DKFZp761G1211, FLJ21033
Protein Interaction Partner: KRTAP5-6, KRTAP10-3, KRTAP4-2, QRICH1, ZHX3, KRTAP5-9, GRN, TP53, MDM2, STAT5A, LEF1, CNOT2, SMAD4, KPNB1, BACH1, TNKS1BP1, FAM222A, C2orf44, CEP97, RNF219, FAM222B, CNOT11, NLK, PASK, SHANK2, UBAP2L, CCP110, TRPS1, TLE3, SKI, RANGAP1, RANBP2, PKM, CNOT3,
Protein Size: 527 - Poids moléculaire
- 58 kDa
- ID gène
- 51701
- NCBI Accession
- NM_016231, NP_057315
- UniProt
- Q9UBE8
- Pathways
- Ubiquitin Proteasome Pathway
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