RIC8A anticorps (N-Term)
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- Antigène Voir toutes RIC8A Anticorps
- RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Lapin, Cheval, Chien, Cobaye
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RIC8A est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- KLTERVGLYR ERSFPHDVQF FDLRLLFLLT ALRTDVRQQL FQELKGVRLL
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 86%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against RIC8A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human RIC8A
- Top Product
- Discover our top product RIC8A Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 537 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))
- Autre désignation
- RIC8A (RIC8A Produits)
- Synonymes
- anticorps RIC8, anticorps AI114950, anticorps RIC-8, anticorps Ric8a, anticorps Ric-8A, anticorps Ric8, anticorps ric-8, anticorps ric8, anticorps synembryn, anticorps xtric-8, anticorps zgc:92294, anticorps Syn, anticorps ric8a, anticorps ric8ab, anticorps CG15797, anticorps DmRic8, anticorps Dmel\\CG15797, anticorps Ric-8, anticorps l(1)G0397, anticorps ric-8a, anticorps ricc8aa, anticorps fj97c10, anticorps synbl, anticorps wu:fj97c10, anticorps RIC8 guanine nucleotide exchange factor A, anticorps microRNA 6743, anticorps synembryn-A, anticorps RIC8 guanine nucleotide exchange factor A L homeolog, anticorps CG15797 gene product from transcript CG15797-RB, anticorps synembryn, anticorps RIC8 guanine nucleotide exchange factor A S homeolog, anticorps Synembryn, anticorps RIC8 guanine nucleotide exchange factor B, anticorps RIC8A, anticorps Ric8a, anticorps ric8a, anticorps MIR6743, anticorps Tsp_08768, anticorps ric8a.L, anticorps LOC411841, anticorps ric8a.S, anticorps ric-8, anticorps ric8b
- Sujet
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RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Alias Symbols: MGC104517, MGC131931, MGC148073, MGC148074, RIC8, synembryn
Protein Interaction Partner: NECAB2, UBQLN1, RABAC1, UBC, EFEMP1, SDCBP, NUTM1, SARNP, WDR61, DPP7, PAPSS2, EZR, UBA1, RPL38, PYGB, PLCG1, MC1R, APEX1, GNAQ, XPO1, GNAI1, UBQLN4, ZNF585B, RIC8A, MAPK8IP3, GNA13, TERF1, GNAI3, GNAI2, GNAS, GNAO1, TUBB2A,
Protein Size: 537 - Poids moléculaire
- 60 kDa
- ID gène
- 60626
- NCBI Accession
- NM_021932, NP_068751
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Asymmetric Protein Localization
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