PRKAR1A anticorps (C-Term)
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- Antigène Voir toutes PRKAR1A Anticorps
- PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
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Épitope
- C-Term
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Reactivité
- Humain, Rat, Souris, Boeuf (Vache), Cobaye, Mouton, Lapin, Chien, Cheval, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PRKAR1A est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MNRPRAATVV ARGPLKCVKL DRPRFERVLG PCSDILKRNI QQYNSFVSLS
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against PRKAR1A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human PRKAR1A
- Top Product
- Discover our top product PRKAR1A Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 381 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
- Autre désignation
- PRKAR1A (PRKAR1A Produits)
- Synonymes
- anticorps ACRDYS1, anticorps ADOHR, anticorps CAR, anticorps CNC, anticorps CNC1, anticorps PKR1, anticorps PPNAD1, anticorps PRKAR1, anticorps TSE1, anticorps 1300018C22Rik, anticorps RIalpha, anticorps Tse-1, anticorps Tse1, anticorps RIIA, anticorps prkar1a, anticorps zgc:92515, anticorps im:7047729, anticorps cnc1, anticorps pkr1, anticorps ppnad1, anticorps prkar1, anticorps tse1, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha, anticorps protein kinase, cAMP dependent regulatory, type I, alpha, anticorps protein kinase cAMP-dependent type 1 regulatory subunit alpha, anticorps protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a, anticorps cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene, anticorps protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog, anticorps PRKAR1A, anticorps Prkar1a, anticorps prkar1aa, anticorps LOC707275, anticorps prkar1a.S
- Sujet
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CAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
Alias Symbols: CAR, CNC, CNC1, DKFZp779L0468, MGC17251, PKR1, PPNAD1, PRKAR1, TSE1, ADOHR
Protein Interaction Partner: UBC, RAF1, MAPT, CEP250, GSK3B, AGO3, AGO2, ARPC3, PFDN5, DYRK1B, SET, DYRK1A, PLEKHF2, AKAP10, SOX2, PRKACB, PRKACA, NPM1, CAPN11, RFC2, PPP1CA, SMAD2, HIVEP1, SETD7, PRPF40A, CDK2, CCNE1, SMURF1, Akap7, MEN1, HSP90AA4P, SLC38A5, PRPF31, SAFB, UBD, PATZ1
Protein Size: 381 - Poids moléculaire
- 43 kDa
- ID gène
- 5573
- NCBI Accession
- NM_212471, NP_997636
- UniProt
- P10644
- Pathways
- Signalisation Hedgehog, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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