MED14 anticorps (Middle Region)

N° du produit ABIN2787568

Détail du produit anti-MED14 anticorps

Antigène: MED14 (Mediator Complex Subunit 14 (MED14))

Épitope: Middle Region

Reactivité: Humain, Souris, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED14 est non-conjugé

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Séquence: AADREDSPAM ALLLQQFKEN IQDLVFRTKT GKQTRTNAKR KLSDDPCPVE

Homologie: Human: 100%, Mouse: 79%, Rabbit: 86%

Attributs du produit: This is a rabbit polyclonal antibody against MED14. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MED14

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1454 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MED14

Antigène: MED14 (Mediator Complex Subunit 14 (MED14))

Autre désignation: MED14 (MED14 Produits)

Synonymes: anticorps CG12031, anticorps Dmel\\CG12031, anticorps Med14, anticorps Trap170, anticorps dTRAP170, anticorps p160, anticorps EXLM1, anticorps crsp150, anticorps crsp2, anticorps trap170, anticorps wu:fd21c05, anticorps wu:fk28h11, anticorps CRSP2, anticorps NV18605, anticorps CRSP150, anticorps CSRP, anticorps CXorf4, anticorps DRIP150, anticorps RGR1, anticorps TRAP170, anticorps 9930001L01Rik, anticorps AU041628, anticorps Crsp2, anticorps ENSMUSG00000073278, anticorps Gm641, anticorps ORF1, anticorps RGD1560170, anticorps Mediator complex subunit 14, anticorps mediator complex subunit 14, anticorps mediator of RNA polymerase II transcription subunit 14, anticorps transcriptional regulation, anticorps MED14, anticorps med14, anticorps LOC100113592, anticorps Med14, anticorps RGR1

Sujet: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Alias Symbols: CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, MGC104513, RGR1, TRAP170
Protein Interaction Partner: UBC, HECW2, CDK8, CDK19, MED12, ESR1, MED19, MED26, PPARG, FBXW7, EPAS1, MED11, MED8, MED29, MED18, MED4, PPP6R1, MED16, MED13, MED24, MED27, MED17, MED21, MED1, CTDP1, SREBF1, DCTN1, ACTN2, ACTN1, MED10, UACA, NECAB2, MED25, MED15, CRSP5, MED7, MED23, VD
Protein Size: 1454

Poids moléculaire: 160 kDa

ID gène: 9282

NCBI Accession: NM_004229, NP_004220

UniProt: O60244

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha