POT1 anticorps (Middle Region)

N° du produit ABIN2787632

Détail du produit anti-POT1 anticorps

Antigène: POT1 (Protection of Telomeres 1 (POT1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Cobaye, Chien, Cheval, Boeuf (Vache), Porc, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POT1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MNSENQTMLS LEFHLHGGTS YGRGIRVLPE SNSDVDQLKK DLESANLTAN

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against POT1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human POT1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 634 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur POT1

Antigène: POT1 (Protection of Telomeres 1 (POT1))

Autre désignation: POT1 (POT1 Produits)

Synonymes: anticorps HPOT1, anticorps POT1, anticorps DKFZp469P1825, anticorps pot1, anticorps 1500031H18Rik, anticorps AI851169, anticorps Pot1, anticorps Pot1a, anticorps protection of telomeres 1, anticorps protection of telomeres 1 L homeolog, anticorps protection of telomeres 1A, anticorps POT1, anticorps pot1.L, anticorps Pot1a, anticorps Pot1

Sujet: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
Alias Symbols: DKFZP586D211, hPot1, HPOT1
Protein Interaction Partner: TPP1, CFL2, ACD, CORO1A, KHDRBS1, LAMC3, BCAS2, MVP, ZNF32, ECI1, CSNK2B, COX6A2, ALDH1A1, ACTN4, SERTAD1, C2orf74, ZBTB49, ZBED2, CYP4F11, MYO5C, RIF1, NAP1L1, MDM2, KRT18, GRN, PACSIN1, SULT4A1, PGLS, AIPL1, SH3BP1, HAAO, NCDN, TWF2, ACOT7, DDX19B, PACS
Protein Size: 634

Poids moléculaire: 70 kDa

ID gène: 25913

NCBI Accession: NM_015450, NP_056265

UniProt: Q9NUX5

Pathways: Cycle Cellulaire, Telomere Maintenance