Caspase 4 anticorps (Middle Region)
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- Antigène Voir toutes Caspase 4 (CASP4) Anticorps
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
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Épitope
- Middle Region
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Caspase 4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG
- Homologie
- Human: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against CASP4. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human CASP4
- Top Product
- Discover our top product CASP4 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 377 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
- Autre désignation
- CASP4 (CASP4 Produits)
- Synonymes
- anticorps ICE(rel)II, anticorps ICEREL-II, anticorps ICH-2, anticorps Mih1/TX, anticorps TX, anticorps Casp11, anticorps CASP13, anticorps CASP1, anticorps CASP4, anticorps Caspl, anticorps ich-3, anticorps Casp4, anticorps caspase 4, anticorps caspase 4, apoptosis-related cysteine peptidase, anticorps caspase-4, anticorps CASP4, anticorps Casp4, anticorps LOC100731032
- Sujet
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This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Alias Symbols: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Protein Interaction Partner: MYH9, ELF4, APP, TRAF6, PLA2G4A, NOD1, CASP14, CASP4, APAF1, SERPINB9, CASP10, IL18, CASP3, IL1B, DSP, PSEN1, IL37, CASP8, CASP1, XIAP, MYCBPAP, SLC25A22, SRPRB, CTNNBIP1, DNAAF5, MTHFD1L, UFL1, GCN1L1, SMC2, NUP93, SMC3, SMC1A, USP9X, VDAC3, PSMB1, MSH6,
Protein Size: 377 - Poids moléculaire
- 10 kDa
- ID gène
- 837
- NCBI Accession
- NM_001225, NP_001216
- UniProt
- P49662
- Pathways
- Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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