USP7 anticorps (Middle Region)

N° du produit ABIN2787924

Détail du produit anti-USP7 anticorps

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP7 est non-conjugé

Application: Western Blotting (WB)

Séquence: RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against USP7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human USP7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1102 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-USP7 (ABIN2787924)

Nie, Zhang, Dai, Zhang, Zhao, Xu, Chen, Wang, Wang, Qiao: "Nicotine Induced Murine Spermatozoa Apoptosis via Up-Regulation of Deubiquitinated RIP1 by Trim27 Promoter Hypomethylation." dans: Biology of reproduction, Vol. 94, Issue 2, pp. 31, (2016) (PubMed).

Détails sur USP7

Antigène: USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) (USP7))

Autre désignation: USP7 (USP7 Produits)

Synonymes: anticorps CG1490, anticorps Dmel\\CG1490, anticorps USP7, anticorps 2210010O09Rik, anticorps AA409944, anticorps AA617399, anticorps AU019296, anticorps AW548146, anticorps C80752, anticorps Hausp, anticorps HAUSP, anticorps TEF1, anticorps UBP, anticorps Ubiquitin-specific protease 7, anticorps ubiquitin carboxyl-terminal hydrolase 7, anticorps ubiquitin specific peptidase 7, anticorps Usp7, anticorps LOC100201254, anticorps USP7

Sujet: USP7 is a hydrolase that deubiquitinates target proteins such as FOXO4, TP53, MDM2, PTEN and DAXX. Together with DAXX, USP7 prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and proteasomal degradation. USP7 deubiquitinates TP53 and MDM2 and strongly stabilizes TP53 even in the presence of excess MDM2, and also induces TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, USP7 is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. USP7 is involved in cell proliferation during early embryonic development. USP7 contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
Alias Symbols: HAUSP, TEF1
Protein Interaction Partner: UBC, TP53, CHFR, RNF220, TPP1, FAM175B, HUWE1, PEPD, XPC, SUMO2, IKBKG, SHFM1, RB1, SUMO1, RPA3, RPA2, RPA1, PTEN, EED, ABL1, RNF2, MMS19, PPP6C, FKBP5, PPP6R3, CDC37, OGFR, COPS6, MAGED2, TRAP1, MCMBP, CLK3, UHRF1, PPARG, RNF11, KAT5, SOX2, LOC576779, HD
Protein Size: 1102

Poids moléculaire: 128 kDa

ID gène: 7874

NCBI Accession: NM_003470, NP_003461

UniProt: Q93009