NAE1 anticorps (C-Term)
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- Antigène Voir toutes NAE1 Anticorps
- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
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Épitope
- C-Term
- Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NAE1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ARALKEFVAK EGQGNLPVRG TIPDMIADSN KYIKLQNVYR EKAKKDAAAV
- Homologie
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%
- Attributs du produit
- This is a rabbit polyclonal antibody against Nae1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C-terminal region of Mouse Nae1
- Top Product
- Discover our top product NAE1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 534 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
- Autre désignation
- Nae1 (NAE1 Produits)
- Synonymes
- anticorps APPBP1, anticorps CG7828, anticorps Dmel\\CG7828, anticorps anon-WO0140519.225, anticorps dAPP-BP1, anticorps dAPPBP1, anticorps A-116A10.1, anticorps ula-1, anticorps Appbp1, anticorps 59kDa, anticorps appbp1, anticorps zgc:66148, anticorps beta-Amyloid precursor protein binding protein 1, anticorps NEDD8 activating enzyme E1 subunit 1, anticorps NEDD8 activating enzyme E1 subunit 1 S homeolog, anticorps nedd8 activating enzyme E1 subunit 1, anticorps NEDD8-activating enzyme E1 regulatory subunit, anticorps APP-BP1, anticorps NAE1, anticorps Nae1, anticorps nae1.S, anticorps nae1, anticorps ula-1
- Sujet
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Nae1 is a regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Alias Symbols: 59 kDa, Appbp1
Protein Size: 534 - Poids moléculaire
- 60 kDa
- ID gène
- 234664
- NCBI Accession
- NM_144931, NP_659180
- UniProt
- Q8VBW6
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