PEN2 anticorps (C-Term)

N° du produit ABIN2788066

Détail du produit anti-PEN2 anticorps

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Chien, Cheval, Cobaye, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEN2 est non-conjugé

Application: Western Blotting (WB)

Séquence: SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PSENEN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human PSENEN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 101 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PEN2

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Autre désignation: PSENEN (PSENEN Produits)

Synonymes: anticorps MSTP064, anticorps PEN-2, anticorps PEN2, anticorps Psenen, anticorps ACYPI006208, anticorps 1700023M09Rik, anticorps Pen-2, anticorps RGD1312037, anticorps CG33198, anticorps Dmel\\CG33198, anticorps anon-AE003800.1, anticorps dPen-2, anticorps psenen, anticorps pen-2, anticorps pen2, anticorps zgc:109727, anticorps presenilin enhancer gamma-secretase subunit, anticorps presenilin enhancer 2, anticorps presenilin enhancer gamma secretase subunit, anticorps Gamma-secretase subunit pen-2, anticorps presenilin enhancer, anticorps presenilin enhancer gamma secretase subunit S homeolog, anticorps PSENEN, anticorps PEN2, anticorps Psenen, anticorps pen-2, anticorps psenen.S, anticorps psenen

Sujet: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A, ERLIN2, THBD, APH1B, PSEN2, PSEN1, TMED10, NCSTN,
Protein Size: 101

Poids moléculaire: 12 kDa

ID gène: 55851

NCBI Accession: NM_172341, NP_758844

UniProt: Q9NZ42

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway