AVPR2 anticorps (C-Term)

N° du produit ABIN2788110

Détail du produit anti-AVPR2 anticorps

Antigène: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin, Mouton, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AVPR2 est non-conjugé

Application: Western Blotting (WB)

Séquence: NPWIYASFSS SVSSELRSLL CCARGRTPPS LGPQDESCTT ASSSLAKDTS

Homologie: Cow: 79%, Dog: 79%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Attributs du produit: This is a rabbit polyclonal antibody against AVPR2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human AVPR2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 371 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur AVPR2

Antigène: AVPR2 (Arginine Vasopressin Receptor 2 (AVPR2))

Autre désignation: AVPR2 (AVPR2 Produits)

Synonymes: anticorps AVPR2, anticorps ADHR, anticorps DI1, anticorps DIR, anticorps DIR3, anticorps NDI, anticorps V2R, anticorps ND1, anticorps VPV2R, anticorps arginine vasopressin receptor 2, anticorps AVPR2, anticorps Avpr2

Sujet: This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
Alias Symbols: ADHR, DI1, DIR, DIR3, MGC126533, MGC138386, NDI, V2R
Protein Interaction Partner: ARRDC4, ARRDC3, GNG2, GNB1, GNAS, STUB1, UBC, DERL1, VCP, C1QTNF1, GRK5, AVP, ARRB2, MAPK3, PRKCA,
Protein Size: 371

Poids moléculaire: 40 kDa

ID gène: 554

NCBI Accession: NM_000054, NP_000045

UniProt: P30518

Pathways: cAMP Metabolic Process