COCH anticorps (N-Term)

N° du produit ABIN2788127

Détail du produit anti-COCH anticorps

Antigène: COCH (Cochlin (COCH))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COCH est non-conjugé

Application: Western Blotting (WB)

Séquence: AHPPTGKRLK KTPEKKTGNK DCKADIAFLI DGSFNIGQRR FNLQKNFVGK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against COCH. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human COCH

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 550 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur COCH

Antigène: COCH (Cochlin (COCH))

Autre désignation: COCH (COCH Produits)

Synonymes: anticorps AW122937, anticorps Coch-5B2, anticorps D12H14S564E, anticorps COCH-5B2, anticorps COCH5B2, anticorps DFNA9, anticorps cochlin, anticorps Coch, anticorps COCH

Sujet: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Alias Symbols: COCH-5B2, COCH5B2, DFNA9
Protein Interaction Partner: FBXO6,
Protein Size: 550

Poids moléculaire: 57 kDa

ID gène: 1690

NCBI Accession: NM_001135058, NP_001128530

UniProt: O43405

Pathways: Sensory Perception of Sound