GCH1 anticorps (C-Term)
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- Antigène Voir toutes GCH1 Anticorps
- GCH1 (GTP Cyclohydrolase 1 (GCH1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cheval, Cobaye, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GCH1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LRPAGVGVVV EATHMCMVMR GVQKMNSKTV TSTMLGVFRE DPKTREEFLT
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against GCH1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human GCH1
- Top Product
- Discover our top product GCH1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 250 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- GCH1 (GTP Cyclohydrolase 1 (GCH1))
- Autre désignation
- GCH1 (GCH1 Produits)
- Synonymes
- anticorps DYT14, anticorps DYT5, anticorps DYT5a, anticorps GCH, anticorps GTP-CH-1, anticorps GTPCH1, anticorps HPABH4B, anticorps GTP-CH, anticorps GTPCH, anticorps Gch, anticorps MGC89622, anticorps gch1a, anticorps wu:fc16b10, anticorps zgc:195269, anticorps GTP cyclohydrolase 1, anticorps GTP cyclohydrolase 1-like, anticorps GCH1, anticorps Gch1, anticorps gch1, anticorps Weevi_1190, anticorps Halhy_0838, anticorps Sinme_1220, anticorps Sphch_1077, anticorps LOC100136794
- Sujet
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This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme.
Alias Symbols: DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
Protein Interaction Partner: GCH1, CALML6, CAMKK1, CSNK1G1, CALML5, PACSIN3, RGS19, MAP2K4, MAPK12, MAP2K5, MAPK10, PRKAR2B, PRKAR2A, PPM1B, CSNK2B, CSNK2A1, GIT2, YWHAZ, CNRIP1, RAB26, AHSA1, SP3, RLF, HSPA8, GCHFR, ATP1B1, CDC37, SH3GL2, OSBPL9, RPH3A,
Protein Size: 250 - Poids moléculaire
- 28 kDa
- ID gène
- 2643
- NCBI Accession
- NM_000161, NP_000152
- UniProt
- P30793
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