DDB2 anticorps (C-Term)

N° du produit ABIN2788357

Détail du produit anti-DDB2 anticorps

Antigène: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Lapin, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDB2 est non-conjugé

Application: Western Blotting (WB)

Séquence: IVVGRYPDPN FKSCTPYELR TIDVFDGNSG KMMCQLYDPE SSGISSLNEF

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 93%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against DDB2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human DDB2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 427 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DDB2

Antigène: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Autre désignation: DDB2 (DDB2 Produits)

Synonymes: anticorps 2610043A19Rik, anticorps si:dkey-45f10.3, anticorps DDBB, anticorps UV-DDB2, anticorps damage specific DNA binding protein 2, anticorps damage-specific DNA binding protein 2, anticorps DDB2, anticorps ddb2, anticorps Ddb2

Sujet: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.
Alias Symbols: DDBB, FLJ34321, UV-DDB2
Protein Interaction Partner: CUL4A, CUL4B, XPC, PARP1, UBC, SUMO1, SMEK1, COPG1, POP1, PSMB4, PSMB1, PSMA5, SEPT2, ARCN1, SUMO2, DDB1, USP24, USP53, RFWD2, COPS4, COPS6, COPS2, COPS3, XPA, TOP1, GRK5, EP300, COPS7A, COPS5, COPS8, RBX1, GPS1, E2F1, DDB2, CUL5, NEDD8, DCLRE1C, vpr, ERC
Protein Size: 427

Poids moléculaire: 48 kDa

ID gène: 1643

NCBI Accession: NM_000107, NP_000098

UniProt: Q92466

Pathways: Réparation de l'ADN