Cyclin-Dependent Kinase 11A (CDK11A) (C-Term) anticorps

N° du produit ABIN2788912

Détail du produit

Antigène: Cyclin-Dependent Kinase 11A (CDK11A)

Épitope: C-Term

Reactivité: Humain, Souris, Chien, Rat, Boeuf (Vache), Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Séquence: EYFRETPLPI DPSMFPTWPA KSEQQRVKRG TSPRPPEGGL GYSQLGDDDL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CDK11A. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 767 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détail du antigène

Antigène: Cyclin-Dependent Kinase 11A (CDK11A)

Autre désignation: CDK11A (CDK11A Produits)

Sujet: This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far.
Alias Symbols: CDC2L2, CDC2L3, p58GTA, PITSLRE, CDK11-p46, CDK11-p58, CDK11-p110
Protein Interaction Partner: UBC, CDC37, FKBP5, PIN1, CDK11A, HKR1, C18orf25, RBM25, ZFP14, PRPF40A, NOP58, ZNF510, ZNF460, ZNF267, ZNF33A, PSMD1, KPNA2, KPNB1, CSNK2B, CSNK2A2, CSNK2A1, CDKN2A, A2M, SOX2, Dlg4, GADD45A, HSP90AA1, SMAD3, SUMO2, CCNL1, SRSF7, RNPS1, KAT7, PAK1, CASP8,
Protein Size: 767

Poids moléculaire: 84 kDa

ID gène: 728642

NCBI Accession: NM_033529, NP_277071

UniProt: Q9UQ88

Pathways: M Phase