EXOSC9 anticorps (N-Term)
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- Antigène Voir toutes EXOSC9 Anticorps
- EXOSC9 (Exosome Component 9 (EXOSC9))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EXOSC9 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ERRFLLRAIE EKKRLDGRQT YDYRNIRISF GTDYGCCIVE LGKTRVLGQV
- Homologie
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against EXOSC9. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product EXOSC9 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 355 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- EXOSC9 (Exosome Component 9 (EXOSC9))
- Autre désignation
- EXOSC9 (EXOSC9 Produits)
- Synonymes
- anticorps scl75, anticorps im:6909054, anticorps zgc:101680, anticorps PM/Scl-75, anticorps PMSCL1, anticorps RRP45, anticorps Rrp45p, anticorps p5, anticorps p6, anticorps Pmscl1, anticorps exosome component 9 L homeolog, anticorps exosome component 9, anticorps exosc9.L, anticorps exosc9, anticorps EXOSC9, anticorps Exosc9
- Sujet
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EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs.
Alias Symbols: PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6
Protein Interaction Partner: UBC, EXOSC4, MPG, AICDA, CSNK2A1, EXOSC5, EXOSC10, EXOSC3, EXOSC2, DIS3, DIS3L, CHMP4B, CAND1, COPS5, CUL3, SUMO2, UBE2I, EXOSC1, SKIV2L2, EXOSC6, DDX39A, MPP6, EXOSC7, EXOSC8, EXOSC9, DDX39B,
Protein Size: 355 - Poids moléculaire
- 39 kDa
- ID gène
- 5393
- NCBI Accession
- NM_005033, NP_005024
- UniProt
- Q06265
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