MC1 Receptor anticorps (C-Term)
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- Antigène Voir toutes MC1 Receptor (MC1R) Anticorps
- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
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Épitope
- C-Term
- Reactivité
- Humain, Souris, Rat, Porc, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MC1 Receptor est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- CPEHPTCGCI FKNFNLFLAL IICNAIIDPL IYAFHSQELR RTLKEVLTCS
- Homologie
- Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 93%, Rat: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against MC1R. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C-terminal region of MC1R
- Top Product
- Discover our top product MC1R Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 317 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
- Autre désignation
- MC1R (MC1R Produits)
- Synonymes
- anticorps CMM5, anticorps MSH-R, anticorps SHEP2, anticorps Mshra, anticorps Tob, anticorps e, anticorps MC1-R, anticorps MSHR, anticorps mc1r, anticorps MC1R, anticorps TUBB3, anticorps melanocortin 1 receptor, anticorps melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), anticorps MC1R, anticorps Mc1r, anticorps mc1r, anticorps mc1r_par1
- Sujet
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This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Alias Symbols: CMM5, MGC14337, MSH-R, SHEP2
Protein Interaction Partner: SUMO2, RIC8A, OGFOD1, TRNT1, EZR, UBA1, PYGL, AHCY, UBC, MGRN1, ASIP, POMC, MC4R,
Protein Size: 317 - Poids moléculaire
- 35 kDa
- ID gène
- 4157
- NCBI Accession
- NM_002386, NP_002377
- UniProt
- Q01726
- Pathways
- cAMP Metabolic Process, Feeding Behaviour
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