Macrophage Scavenger Receptor 1 anticorps (N-Term)
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- Antigène Voir toutes Macrophage Scavenger Receptor 1 (MSR1) Anticorps
- Macrophage Scavenger Receptor 1 (MSR1)
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Épitope
- N-Term
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Reactivité
- Humain, Porc, Chien, Boeuf (Vache), Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- VSSTNANDIT QSLTGKGNDS EEEMRFQEVF MEHMSNMEKR IQHILDMEAN
- Homologie
- Cow: 82%, Dog: 93%, Horse: 85%, Human: 100%, Pig: 82%
- Attributs du produit
- This is a rabbit polyclonal antibody against MSR1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product MSR1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 451 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Macrophage Scavenger Receptor 1 (MSR1)
- Autre désignation
- MSR1 (MSR1 Produits)
- Synonymes
- anticorps CD204, anticorps SCARA1, anticorps SR-A, anticorps SRA, anticorps phSR1, anticorps phSR2, anticorps MRS-A, anticorps MSR, anticorps MSR-A, anticorps SR-AI, anticorps SR-AII, anticorps Scara1, anticorps Scvr, anticorps MSR1, anticorps RGD1564316, anticorps macrophage scavenger receptor 1, anticorps scavenger receptor class A member 5, anticorps MSR1, anticorps Msr1, anticorps SCARA5
- Sujet
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This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Alias Symbols: CD204, SCARA1, SR-A, phSR1, phSR2, SRA
Protein Interaction Partner: SEC22A, LEPROTL1, MALL, NKG7, ATP6V0C, IQCB1, TRAF6, HSPA1A,
Protein Size: 451 - Poids moléculaire
- 50 kDa
- ID gène
- 4481
- NCBI Accession
- NM_138715, NP_619729
- UniProt
- P21757
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