RASGRP1 anticorps (C-Term)

N° du produit ABIN2789624

Détail du produit anti-RASGRP1 anticorps

Antigène: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Épitope: C-Term

Reactivité: Humain, Cobaye, Souris, Lapin, Chien, Cheval, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RASGRP1 est non-conjugé

Application: Western Blotting (WB)

Séquence: LGAKDLLHAP EEGPFTFPNG EAVEHGEESK DRTIMLMGVS SQKISLRLKR

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against RASGRP1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 797 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RASGRP1

Antigène: RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))

Autre désignation: RASGRP1 (RASGRP1 Produits)

Synonymes: anticorps Rasgrp, anticorps CALDAG-GEFI, anticorps CALDAG-GEFII, anticorps RASGRP, anticorps V, anticorps hRasGRP1, anticorps RAS guanyl releasing protein 1, anticorps Rasgrp1, anticorps RASGRP1

Sujet: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Alias Symbols: CALDAG-GEFI, CALDAG-GEFII, MGC129998, MGC129999, RASGRP, V, hRasGRP1
Protein Interaction Partner: Dlg4, ABCB8, DGKZ, HRAS, VHL, PPM1B,
Protein Size: 797

Poids moléculaire: 90 kDa

ID gène: 10125

NCBI Accession: NM_005739, NP_005730

UniProt: O95267

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway