FLNC anticorps (N-Term)

N° du produit ABIN2789843

Détail du produit anti-FLNC anticorps

Antigène: FLNC (Filamin C, gamma (FLNC))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLNC est non-conjugé

Application: Western Blotting (WB)

Séquence: VGKSADFVVE AIGTEVGTLG FSIEGPSQAK IECDDKGDGS CDVRYWPTEP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against FLNC. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human FLNC

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 2692 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FLNC (ABIN2789843)

Begay, Tharp, Martin, Graw, Sinagra, Miani, Sweet, Slavov, Stafford, Zeller, Alnefaie, Rowland, Brun, Jones, Gowan, Mestroni, Garrity, Taylor: "FLNC Gene Splice Mutations Cause Dilated Cardiomyopathy." dans: JACC. Basic to translational science, Vol. 1, Issue 5, pp. 344-359, (2016) (PubMed).

Détails sur FLNC

Antigène: FLNC (Filamin C, gamma (FLNC))

Autre désignation: FLNC (FLNC Produits)

Sujet: This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: ABP-280, ABP280A, ABPA, ABPL, FLJ10186, FLN2
Protein Interaction Partner: RAPGEF2, TRIM63, TRIM55, XIRP1, XIRP2, SYNPO2, UBC, KCMF1, CTTNBP2NL, ANKRD28, ARFGEF2, NCAPD2, TXNL1, PSMD13, PSMD12, PSMD3, NUP88, IKBKB, FLNB, AP3S1, NPM1, IGSF8, FN1, IQCB1, TP63, VCAM1, RPS6KA2, DYNLRB1, NUP133, SAP30BP, SF3A3, SRSF9, ENO1, EEF1G, EE
Protein Size: 2692

Poids moléculaire: 296 kDa

ID gène: 2318

NCBI Accession: NM_001127487, NP_001120959

UniProt: Q14315